The National Cancer Institute created originally the Common Toxicity Criteria (CTC) to aid in the recognition and grading severity of adverse effects caused by chemotherapy treatments.
NCI-CTCAE Grading Scale*
|Grade 0 (none)
|Grade 1 (mild)
||Painless ulcers, erythema, or mild soreness in the absence of lesions
|Grade 2 (moderate)
||Painful erythema, oedema, or ulcers but eating or swallowing possible
|Grade 3 (severe)
||Painful erythema, oedema, or ulcers requiring IV hydration
|Grade 4 (life-threatening)
||Severe ulceration or requiring parenteral or enteral nutritional support or prophylactic intubation
|Grade 5 (death)
||Death related to toxicity
* Specific NCI-CTC grading scales related to radiation and bone marrow transplantation have been formulated and are described in Sonis et al. 2004.
NCI-CTC v 2.0, 1999 : http://ctep.cancer.gov/
Sonis et al. Cancer 2004; 100(9 Suppl):1995-2025.